ea0037ep98 | Steroids, development and paediatric endocrinology | ECE2015
Zivkovic Lada
, Spremo-Potparevic Biljana
, Djelic Ninoslav
, Bajic Vladan
Oestrogen has very complex effects on the CNS. It protects neurons from noxious effects of β amyloid in vitro, ameliorates the cerebral metabolism and increases the level of acetylcholine in the basal forebrain and hippocampus. Its beneficial impact in Alzheimer disease may be attributed in part to its antioxidant activity. On the other hand, it has been demonstrated that oestrogens may exhibit genotoxic effects, especially at elevated tissue concentrations. Ther...